British Journal of Venereal Diseases, Vol 52, Issue 1 43-45, Copyright © 1976 by Sexually Transmitted Infections
Minocycline hydrochloride (Minocin) as a single-dose oral treatment of uncomplicated gonorrhoea in men
G Masterton and CB Schofield
349 male patients with uncomplicated gonococcal urethritis were treated
with a single dose of 300 mg. or 400 mg. minocycline hydrochloride. The
lower dose gave a lower failure rate, 3-2 compared with 5-1 per cent., but
this difference was not statistically significant. The overall known
failure rate of 4-2 per cent. compares most favourably with our previous
findings in this area using other drugs of the tetracycline group. The
incidence of post-gonococcal urethritis (5-1 per cent.) was also the lowest
we have found. The few side-effects reported were comparatively trivial.
Because of its high degree of therapeutic efficacy, the relatively lack of
side-effects, and the reduced incidence of post-gonococcal urethritis,
minocycline hydrochloride should be considered the drug of choice whenever
single-dose oral treatment is given in uncomplicated gonorrhoea in men.
