Genitourinary Medicine, Vol 62, Issue 3 170-174, Copyright © 1986 by Sexually Transmitted Infections
Evaluation of ciprofloxacin 500 mg twice daily for one week in treating uncomplicated gonococcal chlamydial, and non-specific urethritis in men
OP Arya, D Hobson, CA Hart, C Bartzokas and BC Pratt
Ciprofloxacin, a quinolone antibacterial, was evaluated in the treatment of
gonococcal, chlamydial, gonococcal and chlamydial, and non-gonococcal
non-chlamydial urethritis. The dosage regimen used was 500 mg orally twice
a day for seven days. Of the 56 patients evaluated 22 had gonococcal
infection only, 13 were infected with Chlamydia trachomatis only, seven had
combined infection, and 14 were harbouring neither of these organisms.
Neisseria gonorrhoeae was cleared in all the 29 patients with or without
chlamydial infection. Of those who denied having sexual intercourse during
the follow-up period, post gonococcal urethritis (PGU) developed in 12
(63%) out of 19, C trachomatis was isolated again from 11 (78%) out of 14,
and urethritis recurred in five (55%) out of nine patients with
non-gonococcal non-chlamydial infection. There was also evidence that the
dosage regimen used was only partially effective against Ureaplasma
urealyticum.
