The incidence of uveitis caused by syphilis has fluctuated during the past century. This paper suggests ways in which the diagnosis of this condition may be helped by reactions to chemotherapy. It also reports on a 22 year old woman presenting with anterior uveitis due to secondary syphilis, who rapidly developed bilateral papilloedema on starting antisyphilitic chemotherapy. She later developed psychiatric symptoms which were partly the result of corticosteroid treatment.
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