rss
Genitourin Med 1986;62:166-169 doi:10.1136/sti.62.3.166
  • Research Article

Resistance in Escherichia coli after single dose ampicillin to treat gonorrhoea.

  1. F M Mulcahy,
  2. C J Lacey,
  3. K Barr,
  4. R W Lacey

      Abstract

      Patients with uncomplicated gonorrhoea were treated with a single dose of either ampicillin 3 g orally or procaine penicillin 2.4 MIU by injection, both with probenecid 1 g orally. The proportion of faecal Escherichia coli resistant to ampicillin before and a week after treatment was assessed. Of 55 patients treated with ampicillin who initially possessed sensitive flora, 25 (45.5%) became colonised subsequently by resistant E coli. Resistance to ampicillin, together with resistance to some other antimicrobials, was transferable in vitro. Penicillin, however, selected resistant E coli in only four (14.3%) out of 28 patients with initially sensitive flora. There was no difference in therapeutic response between the two agents. Intramuscular penicillin appeared to offer appreciably greater microbiological benefits than oral ampicillin in treating gonorrhoea.

      This Article

      1. Abstract
      2. PDF

      Responses

      1. Submit a response
      2. No responses published

      Register for free content

      The full back archive is now available for all BMJ Journals. Institutional subscribers may access the entire archive as part of their subscription. Personal subscribers will also have access to all content when logged in. Non-subscribers who register have free access to all articles published before 2006 right back to volume 1 issue 1. Register here to access the free archive of all BMJ Journals.

      Don't forget to sign up for content alerts so you keep up to date with all the articles as they are published.