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Hepatitis B in symptomless Danish homosexual men.
  1. L K Munck,
  2. C S Petersen,
  3. K Bech,
  4. A C Thomsen,
  5. S Kroon,
  6. A M Worm,
  7. G L Wantzin,
  8. J Gerstoft
  1. Department of Medical Gastroenterology, Bispebjerg Hospital, Copenhagen, Denmark.

    Abstract

    Forty eight symptomless homosexual men attending a sexually transmitted disease (STD) clinic and found by screening to have hepatitis B surface antigen (HBsAg) were followed up for a median of 10 (range six to 26) months to characterise their liver disease. Initially 33/50 (66%) of the men had increased serum liver enzyme activity and 19/47 (40%) had increased serum immunoglobulin G concentrations. Liver biopsy specimens showed acute hepatitis B in 12 (39%) and chronic hepatitis B in 19 (61%) of the 31 patients who underwent liver biopsy. The course of the infection was: acute hepatitis B in 14/48 (29%), chronic persistent hepatitis B in 23/48 (48%), chronic aggressive hepatitis B in 8/48 (17%), and cirrhosis in 3/48 (6%) of the patients. Antibodies against human immunodeficiency virus (HIV) were present in 16/45 (36%) of the patients, but the presence of antibodies to HIV did not influence the course of hepatitis B in the observation period.

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