Lichen sclerosus of the glans is significantly associated with penile carcinoma

Table 1

Clinical and histopathological features of eight cases of carcinoma on penile lichen sclerosus

Patient No	Age of onset of PLS (years)	Age of onset of Ca (years)	Lag time (years)	Site	Clinical aspect of malignancy on PLS	Histopathology	PCR testing for HPV
*Previously reported cases.¹
PLS = penile lichen sclerosus; Ca = carcinoma; PCR = polymerase chain reaction; HPV = human papillomavirus; SCC = squamous cell carcinoma; VC = verrucous carcinoma.
1*	41	62	21	glans	fungating keratotic nodule with a white-yellowish hue	SCC	negative
						well differentiated
2*	36	59	23	glans	slightly elevated verrucous papules	SCC	HPV 16
						well differentiated
3*	41	55	14	glans, coronary sulcus	multiple erythematous, indurated, and ulcerated plaques	SCC	HPV 16
						well differentiated
4*	39	49	10	glans, coronary sulcus, inner aspect of the foreskin	sharply circumscribed, erythematous, eroded, oozing, and slightly infiltrated plaque	In situ carcinoma	HPV 16
5*	29	47	18	glans	exophytic verrucous whitish nodule	VC	HPV 16
6	75	85	10	glans	sharply circumscribed, erythematous, and ulcerated plaque	SCC	HPV 16
						well differentiated
7	66	70	15	glans	exophytic whitish and indurated plaque	SCC	negative
						undifferentiated
8	33	67	34	glans, coronary sulcus	sharply circumscribed, erythematous, eroded, crusted, and indurated plaque	SCC	negative
						undifferentiated