Sex Transm Infect 77:409-412 doi:10.1136/sti.77.6.409

Podophyllin office therapy against condyloma should be abandoned

  1. Geo von Krogh1,
  2. Eric Longstaff2
  1. 1Department of Dermatovenereology, Karolinska Hospital, 17176, Stockholm, Sweden
  2. 2Pre-clinical Development Services Ltd, Stockport, UK
  1. Dr von Krogh geo.von.krogh{at}
  • Accepted 22 May 2001


Podophyllin, a crude plant extract with low efficacy, high toxicity, and a serious mutagenicity profile does not comply with the WHO guidelines for plant derived treatments and should be removed from clinical treatment protocols. Home treatment with pharmaceutical products based on podophyllotoxin—the purified, standardised active antiwart ingredient of podophyllin—represents safe and effective first line therapy for patients with anogenital warts.