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Sex Transm Infect 78:139-142 doi:10.1136/sti.78.2.139
  • Clinicopathological conference

Lactic acidosis and abnormal liver function in advanced HIV disease

  1. M Shahmanesh1,
  2. J Cartledge1,
  3. R Miller2
  1. 1Department of Genito-Urinary Medicine, Mortimer Market Centre, Camden and Islington Community Health Services NHS Trust, London WC1E 6AU, UK
  2. 2Department of Sexually Transmitted Diseases, Windeyer Institute of Medical Sciences, Royal Free and University College Medical School, University College London and Mortimer Market Centre, Camden and Islington Community Health Services NHS Trust, London WC1E 6AU, UK
  1. Correspondence to:
 Dr R F Miller, Department of Sexually Transmitted Diseases, Windeyer Institute of Medical Sciences, Royal Free and University College Medical School, University College London and Mortimer Market Centre, Camden and Islington Community Health Services NHS Trust, London WC1E 6AU, UK
 rmiller{at}gum.ucl.ac.uk
  • Accepted 24 January 2002

Abstract

A 48 year old man receiving HAART presented with late stage HIV disease, non-specific symptoms, a normal sized liver, ascites, and lactic acidosis. Following a failed liver biopsy worsening acidosis developed, requiring ICU support. Progressive liver failure occurred. Endoscopy showed oesophageal varices and a transjugular liver biopsy showed non-cirrhotic cholestasis; findings that were ascribed to HAART.

Footnotes