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Analysis of Chlamydia trachomatis serovar distribution changes in the Netherlands (1986–2002)
  1. J Spaargaren1,
  2. I Verhaest1,
  3. S Mooij1,
  4. C Smit2,
  5. H S A Fennema3,
  6. R A Coutinho4,
  7. A Salvador Peña5,
  8. S A Morré5
  1. 1Public Health Laboratory, Municipal Health Service, Amsterdam, Netherlands
  2. 2Cluster Infectious Diseases, Department of HIV and STI Research, Municipal Health Service, Amsterdam, Netherlands
  3. 3Sexual Transmitted Diseases Outpatient Clinic, Municipal Health Service, Amsterdam, Netherlands
  4. 4Municipal Health Service, Amsterdam, Netherlands
  5. 5Laboratory of Immunogenetics, Section Immunogenetics of Infectious Diseases, VU University Medical Center, Amsterdam, Netherlands
  1. Correspondence to:
 Joke Spaargaren, MD
 Public Health Laboratory, Municipal Health Service of Amsterdam, Nieuwe Achtergracht 100, 1018 WT, Amsterdam, Netherlands; jspaargarengggd.amsterdam.nl

https://doi.org/10.1136/sti.2003.006395

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    Up to 19 different Chlamydia trachomatis (CT) serovars which are pathogenic predominantly for the urogenital tract and numerous CT variants have been identified.1,2 An increasing number of isolates are typed worldwide and provide a wealth of information on the epidemiology of CT infections, a sexually transmitted disease (STD) for which screening has been proposed.3–5 Recent studies have demonstrated an association between CT serovar G and squamous cell carcinoma.6 A possible shift in the serovar distribution over time in a region or country could reveal information on changes in the epidemiology of CT infections and could potentially have clinical implications.

    We therefore determined the CT serovar distribution in a large STD population in Amsterdam in 2000–2 and compared it together with all published serovar distributions since 1986 in the Netherlands to assess if serovar distribution shifts over time occurred.

    Of people attending the STD outpatient clinic in Amsterdam from 2000–2, those found CT positive (n = 407) by LCx (Abbott Laboratories, Chicago, IL, USA) were genotyped as described previously.1 This is the largest STD population typed to date in The Netherlands. The following serovar distribution was found: B = 1%; D = 12%; Da = 0.2%; D- = 1%: E = 33%; F = 23%; …

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