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Sex Transm Infect 2004;80:315-317 doi:10.1136/sti.2003.008474
  • Case report

Unusual muscle disease in HIV infected patients

  1. S Roedling1,
  2. D Pearl1,
  3. H Manji2,
  4. M G Hanna2,
  5. J L Holton3,
  6. R F Miller1,4
  1. 1Patrick Manson Unit, University College London Hospitals, London WC1E 6AU, UK
  2. 2Centre for Neuromuscular Disease, Department of Molecular Neuroscience, Institute of Neurology, University College London and National Hospital for Neurology and Neurosurgery, London WC1N 3BG, UK
  3. 3Department of Molecular Neuroscience and Division of Neuropathology, Institute of Neurology, University College London and National Hospital for Neurology and Neurosurgery, London WC1N 3BG, UK
  4. 4Centre for Sexual Health and HIV Research, Department of Primary Care and Population Sciences, Royal Free and University College Medical School, University College London, and Camden Primary Care Trust, Mortimer Market Centre, London WC1E 6AU, UK
  1. Correspondence to:
 Dr Rob Miller
 Centre for Sexual Health and HIV Research, Department of Primary Care and Population Sciences, Royal Free and University College Medical School, University College London, and Camden Primary Care Trust, Mortimer Market Centre, London WC1E 6AU, UK; rmillergum.ucl.ac.uk.uk
  • Accepted 9 February 2004

Abstract

Two patients presented with proximal muscle weakness, a normal or minor elevation of creatine phosphokinase (CPK) and normal findings on electromyography. Muscle biopsy in one patient revealed CD8+ polymyositis, and in the other showed ddI induced myopathy. These cases illustrate the importance of muscle biopsy in identifying the underlying pathology in HIV infected patients with muscle weakness and little or no abnormality in laboratory investigations.

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