Sex Transm Infect 82:236-237 doi:10.1136/sti.2005.017764
  • HIV

Post-exposure HIV prophylaxis following sexual exposure: a retrospective audit against recent draft BASHH guidance

  1. S Day,
  2. A Mears,
  3. K Bond,
  4. R Kulasegaram
  1. Lydia Department, Guy’s and St Thomas’s Hospitals, London SE1 7EH, UK
  1. Correspondence to:
 Dr R Kulasegaram
 Lydia Department, St Thomas’s Hospital, Lambeth Palace Road, London SE1 7EH, UK; doctor_saraday{at}
  • Accepted 13 December 2005


Objectives: To retrospectively audit the management of post-exposure HIV prophylaxis following sexual exposure (PEPSE) against the British Association for Sexual Health and HIV 2004 draft guidance.

Methods: A retrospective review of case notes from January 2000 to November 2004. The draft guidelines were not adopted into clinical practice during the study period.

Results: 76 patients received PEPSE. 79% (95% CI 68.08 to 87.46) of PEPSE prescriptions were given for exposures that were in accordance with the guidelines’ recommended indications (target 90%). 87% (95% CI 77.13 to 93.51) of PEPSE was prescribed within 72 hours of risk exposure (target 90%). 91% (95% CI 81.94 to 96.22) of recipients received a recommended antiretroviral combination. 53% (95% CI 40.84 to 64.21) of recipients completed the PEPSE course (target 75%). 45% of patients attended for the 3 month follow up HIV test but only 12% (95% CI 5.56 to 21.29) attended for both the 3 month and 6 month HIV test (target 75%).

Conclusion: PEPSE is predominantly being prescribed for recommended indications and is dispensed within 72 hours of risk exposure. PEPSE completion rates and attendance for 3 months and 6 months post-exposure HIV testing need improving, perhaps by introducing a PEPSE clinic.


  • Conflict of interest: The authors have received financial assistance from pharmaceutical companies.

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