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Increase in hepatitis C virus incidence in HIV-1-infected patients followed up since primary infection
  1. J Ghosn1,
  2. C Deveau2,
  3. C Goujard3,
  4. I Garrigue4,
  5. N Saïchi2,
  6. J Galimand1,
  7. Z Nagy2,
  8. C Rouzioux1,
  9. L Meyer2,
  10. M-L Chaix1,
  11. for the French PRIMO Cohort Study Group (ANRS CO 06)
  1. 1Laboratoire de Virologie, Université René Descartes Paris 5, CHU Necker-Enfants Malades, Paris, France
  2. 2Epidemiology, Demography and Social Sciences, INSERM, National Institute of Health and Medical Research, Le Kremlin-Bicêtre, France; University Paris-Sud 11, Faculté de Médecine, Le Kremlin-Bicêtre, France; AP-HP, Assistance Publique-Hôpitaux de Paris, Hôpital Bicêtre, Le Kremlin-Bicêtre, France
  3. 3Service de Médecine Interne et INSERM E109, CHU Bicêtre, Le Kremlin-Bicêtre, France
  4. 4Laboratoire de Virologie, CHU Pellegrin, Bordeaux, France
  1. Correspondence to:
 Dr Jade Ghosn
 Laboratoire de Virologie, EA MRT 3620, Université René Descartes Paris5, CHU Necker-Enfants Malades, 149 Rue de Sèvres, 75015 Paris, France; jade.ghosn{at}bct.ap-hop-paris.fr

Abstract

Background: An increase in the incidence of sexually transmitted infections and hepatitis C virus (HCV) infections in HIV-infected men who have sex with men (MSM) has recently been reported.

Objective: To estimate HCV incidence and risk factors among HIV-1-infected patients followed up since primary HIV infection in the French PRIMO Cohort between 1996 and 2005.

Patients and methods: All patients with at least 18 months of follow-up were studied. HCV antibody tests were performed on baseline plasma samples and repeated on the latest available sample when negative at baseline.

Results: In total, 402 patients with a median follow-up of 36 (range 18–104) months were eligible. HCV seroconversion was observed in 6 patients (4 men and 2 women), corresponding to an HCV incidence rate of 4.3 per 1000 person-years. Incidence rates in men and women were 3.5 and 7.8 per 1000 person-years, respectively. The incidence rate was 1.2 per 1000 person-years before January 2003 and 8.3 per 1000 person-years after January 2003 (p = 0.06). The classic risk factors for HCV infection were found in women (intravenous drug use, and body piercing), whereas the only identified risk factor for HCV acquisition was unsafe sex in the four men.

Conclusions: Increase in the incidence of acute HCV infection in recently HIV-infected patients confirms the shift in sexual behaviour in the recent years, especially in HIV-infected MSM. Repeated testing for HCV antibodies should be carried out in HCV-negative HIV-infected patients and specific recommendations about protected sex should be clearly provided.

  • HCV, hepatitis C virus
  • IVDU, intravenous drug use
  • MSM, men who have sex with men
  • PHI, primary HIV infection
  • STI, sexually transmitted infection

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Footnotes

  • Published Online First 21 August 2006

  • Funding: This study was supported by a scholarship from Sidaction-Ensemble Contre le Sida (JG) and funded by the French National Agency for Research on AIDS.

  • Competing interests: None declared.

  • Part of this study was presented at the 13th Conference on Retroviruses and Opportunistic Infections, Denver, Colorado, USA, February 2006.

    Contributors: : JG: clinical coordination, study design, paper writing; CD: coordination of the PRIMO Cohort, sample monitoring, statistical analysis; CG: referent physician of the PRIMO Cohort study, study design, paper writing; IG: virology assessments; NS and ZN: study monitoring of the PRIMO Cohort; J Galimand: virology assessments; CR: referent virologist of the PRIMO Cohort, study design, paper writing; LM: principal investigator of the PRIMO Cohort, study design, satistical analysis, paper writing; M-LC: principal investigator, study design, virological validation, paper writing.

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