Article Text

PDF
Relative prevalence of different sexually transmitted infections in HIV-discordant sexual partnerships: data from a risk network study in a high-risk New York neighbourhood
  1. S R Friedman1,
  2. M Bolyard2,
  3. M Sandoval1,
  4. P Mateu-Gelabert1,
  5. C Maslow3,
  6. J Zenilman4
  1. 1
    National Development and Research Institutes, Inc, New York, NY, USA
  2. 2
    Borough of Manhattan Community College, New York, NY USA
  3. 3
    New York City Department of Health, New York, NY, USA
  4. 4
    Johns Hopkins Bayview Medical Center, Baltimore, MD, USA
  1. Dr S R Friedman, National Development and Research Institutes, Inc, 71 W 23rd Street, 8th floor, New York, NY 10010, USA; friedman{at}ndri.org

Abstract

Objectives: To determine infection patterns of sexually transmitted infections that facilitate HIV transmission among HIV-discordant couples.

Methods: 112 initial respondents were recruited in an impoverished neighbourhood of Brooklyn, New York. Their sexual (and injection) partners were recruited in up to four additional network sampling waves for a final sample of 465 persons aged 18 years or older. After separate informed consent had been obtained, blood and urine were collected and tested for HIV, type-specific antibodies to herpes simplex virus (HSV-2), syphilis, chlamydia and gonorrhoea.

Results: Of 30 HIV-discordant partnerships, five were same-sex male partnerships and 25 were opposite-sex partnerships. No subjects tested positive for syphilis or gonorrhoea. Two couples were chlamydia-discordant. For HSV-2, 16 couples were double-positive, eight discordant, four double-negative, and two comprised a HSV-2-negative with a partner with missing herpes data.

Conclusions: HSV-2 was present in 83% of the HIV-discordant couples, chlamydia in 7%, and syphilis and gonorrhoea in none. HSV-2 is probably more important for HIV transmission than bacterial sexually transmitted diseases because it is more widespread. Even given the limited generalisability of this community-based sample, there seems to be an important HIV-prevention role for herpes detection and prevention activities in places where HIV-infected people are likely to be encountered, including sexually transmitted disease clinics, HIV counselling and testing programmes, prisons, needle exchanges, and drug abuse treatment programmes. The effects of HSV-suppressive therapy in highly impacted groups should also be investigated.

Statistics from Altmetric.com

Footnotes

  • Funding: Funding was provided by US National Institute on Drug Abuse (NIDA) project R01 DA13128 (Networks, Norms, and HIV/STI Risk among Youth). NIDA had no role beyond that in the creation of this paper.

  • Competing interests: None.

Request permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.

Linked Articles

  • Brief encounters
    Helen Ward Rob Miller