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Epidemiology of human papillomavirus infection among fishermen along Lake Victoria Shore in the Kisumu District, Kenya
  1. M O Ng’ayo1,
  2. E Bukusi1,2,
  3. A Rowhani-Rahbar3,
  4. L A Koutsky3,4,
  5. Q Feng5,
  6. Z A Kwena1,
  7. K K Holmes4
  1. 1
    Center for Microbiology Research, Kenya Medical Research Institute, Nairobi, Kenya
  2. 2
    Department of Obstetrics and Gynecology, University of Nairobi, Kenya
  3. 3
    Department of Epidemiology
  4. 4
    Center for AIDS and STD
  5. 5
    Department of Pathology, University of Washington, Seattle, Washington, USA
  1. Musa Otieno Ng’ayo, Kenya Medical Research Institute, CMR-UCSF Building, Lumumba Health Center, PO Box 614 - 40100 Kisumu, Kenya; motieno{at}kemri-ucsf.org

Abstract

Objectives: The epidemiology of human papillomavirus (HPV) infection in men in Kenya is largely uncharacterised. We set out to determine the prevalence and determinants of HPV infection among sexually active fishermen along Lake Victoria in the Kisumu district of Kenya.

Methods: Genital swabs were obtained from 250 consenting fishermen from 18 beaches and a detailed sociodemographic questionnaire was administered. HPV positivity was determined by polymerase chain reaction amplification and detected by dot blot hybridisation with generic HPV and β-globin probes. HPV positive samples were genotyped using the Roche Linear array assay.

Results: Overall, 144 (57.6%) fishermen had detectable HPV DNA, 106 (42.4%) were infected with oncogenic HPV types, with HPV-16 being the most frequent type (12.4%). Among HPV positive men, 105 (72.9%) were infected with more than one HPV type and 20 (13.9%) were infected with more than six different types. HIV seropositive men (PR 1.49, 95% CI 1.19 to 1.86) and those divorced or separated (PR 1.62, 95% CI 1.13 to 2.33) were more likely to be infected with HPV. HIV infection (PR 1.22, 95% CI 1.01 to 1.47) was the only factor independently associated with infection with multiple types of HPV.

Conclusion: The prevalence of oncogenic HPV infection is high among this population and is associated with HIV serostatus and marital status. This community could benefit from enhanced sexually transmitted infection and HIV prevention interventions.

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Footnotes

  • MON performed laboratory analyses and was lead author for the paper; EB and KKH conceived and designed the study; LK and AR analysed and interpreted the data; QF performed laboratory analyses; ZK supervised the conduct of the trial and data acquisition; all authors contributed to the write up.

  • Funding: The study was funded, in part, by the National Institute of Allergy and Infectious Disease UW STI-TM CRC Grant U19-AI31448. Ng’ayo was supported by the International AIDS and Research Training Grant from the Fogarty Institute of the NIH.

  • Competing interests: None.

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