This article has a correction

Please see: Sex Transm Infect 2008;84:328

Sex Transm Infect 84:161-166 doi:10.1136/sti.2007.029512
  • Clinical

Estimation of the impact of genital warts on health-related quality of life

  1. S Woodhall1,2,
  2. T Ramsey2,
  3. C Cai2,
  4. S Crouch1,
  5. M Jit3,
  6. Y Birks1,
  7. W J Edmunds3,
  8. R Newton1,
  9. C J N Lacey2,4
  1. 1
    Department of Health Sciences, University of York, York, UK
  2. 2
    Sexual Health and HIV Research Unit, Department of GU Medicine, York, UK
  3. 3
    Modelling and Economics Unit, Health Protection Agency, London, UK
  4. 4
    Hull York Medical School, University of York, York, UK
  1. S Woodhall, Sexual Health and HIV Research Unit, Department of GU Medicine, 31 Monkgate, York YO31 7WA, UK; sarah.woodhall{at}
  • Accepted 29 February 2008
  • Published Online First 13 March 2008


Objectives: One of the two new human papillomavirus (HPV) vaccines protects against HPV types 6 and 11, which cause over 95% of genital warts, in addition to protecting against HPV types 16 and 18. In anticipation of HPV vaccine implementation, the impact of genital warts on health-related quality of life (HRQoL) was measured to assess the potential benefits of the quadrivalent over the bivalent vaccine.

Methods: Genitourinary medicine clinic patients aged 18 years and older with a current diagnosis of genital warts were eligible; 81 consented and were interviewed by a member of the research team. A generic HRQoL questionnaire, the EQ-5D (comprising EQ-5D index and EQ visual analogue scale (VAS) scores) and a disease-specific HRQoL instrument, the CECA10, were administered. Previously established UK population norms were used as a control group for EQ-5D comparisons.

Results: Cases (with genital warts) had lower EQ VAS and EQ-5D index scores than controls. After adjusting for age a mean difference between cases and controls 30 years of age and under (n  =  70) of 13.9 points (95% CI 9.9 to 17.6, p<0.001) for the EQ VAS and 0.039 points (95% CI 0.005 to 0.068, p = 0.02) on the EQ-5D index (also adjusted for sex) was observed. The difference between cases and controls for the EQ VAS was especially notable in young women.

Conclusions: Genital warts are associated with a significant detriment to HRQoL. The potential added benefit of preventing most cases of genital warts by HPV vaccination should be considered in decisions about which HPV vaccine to implement in the United Kingdom.


  • Contributors: CJNL was the chief investigator for the study. SW, CJNL, MJ, WJE and RN designed the study. SW, TR and CC carried out the data collection. SW and SC performed the statistical analyses. SW wrote the manuscript with contributions from all authors.

  • Funding: This work was supported by funding from a Department of Health Grant “Studies to inform the design, implementation and monitoring of a human papillomavirus vaccination programme in England”, grant no 039/0030. The funding body were not involved in the design of the study, nor the analysis or write-up and were not involved in the decision to submit the manuscript.

  • Competing interests: None.

  • Ethics approval: The study was approved by the South Humber Research Ethics Committee.

Free sample

This recent issue is free to all users to allow everyone the opportunity to see the full scope and typical content of STI.
View free sample issue >>

Don't forget to sign up for content alerts so you keep up to date with all the articles as they are published.

Navigate This Article