rss
Sex Transm Infect 2008;84:350-351 doi:10.1136/sti.2007.028837
  • Clinical

Detection of acute HIV infections among sexually transmitted disease clinic patients: a practice in Guangxi Zhuang Autonomous Region, China

  1. Y-P Yin1,
  2. X-S Chen1,
  3. H-C Wang1,
  4. M-Q Shi1,
  5. W-H Wei1,
  6. B-Y Zhu2,
  7. Y-H Yu1,
  8. J D Tucker3,
  9. M S Cohen4
  1. 1
    National Center for STD Control, Chinese Academy of Medical Sciences & Peking Union Medical College Institute of Dermatology, Nanjing, China
  2. 2
    Guangxi Autonomous Region Institute of Dermatology, Nanning, China
  3. 3
    Massachusetts General Hospital, Boston, USA
  4. 4
    School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, USA
  1. Dr Xiang-Sheng Chen, National Center for STD Control, 12 Jiangwangmiao Street, Nanjing 210042, China; chenxs{at}vip.163.com
  • Accepted 18 February 2008
  • Published Online First 27 February 2008

Abstract

Detection of people with acute HIV infection (AHI) affords an important opportunity for early HIV treatment and prevention. HIV RNA reverse transcriptase-polymerase chain reaction (RT-PCR) testing with two-stage pooling scheme was used to detect the AHI in specimens collected from sexually transmitted disease (STD) clinic patients in Guangxi, China. A total of 246 HIV RNA tests were required to screen 11 395 samples negative for conventional enzyme immunoassay (EIA) and Western blot assays, and five AHI cases (0.04%, 95%CI 0.02% to 0.10%) with a high viral load (median of 265 677 copies per ml) were detected. The total expenditure for RT-PCR testing reflected an added cost of $2.9 per specimen screened and $6575 per additional case of AHI identified among the study population. This study supports the feasibility of pooled RNA testing in addition to detection of HIV infections among patients at STD clinics in China, but the cost effectiveness should be carefully considered.

Footnotes

  • Competing interests: None.

  • Ethics approval: This study was approved by the Protection of the Rights of Human Subjects Institutional Review Board (IRB) at the UNC at Chapel Hill and the Medical Ethics Committee at the National Center for STD Control (NCSTD).

  • Contributors: XSC and MSC were principal investigators who were responsible for the study design, data analysis and manuscript preparation. YPY was responsible for study design and laboratory implementation. JDT helped with study design and manuscript preparation. HCW and BYZ were responsible for field coordination. MQS, WHW and YHY were the laboratory based senior technicians who were responsible for laboratory testing.

This Article

  1. Abstract
  2. Full text
  3. PDF
  4. All versions of this article:
    1. sti.2007.028837v1
    2. 84/5/350 most recent

Responses

  1. Submit a response
  2. No responses published

Register for free content

The full back archive is now available for all BMJ Journals. Institutional subscribers may access the entire archive as part of their subscription. Personal subscribers will also have access to all content when logged in. Non-subscribers who register have free access to all articles published before 2006 right back to volume 1 issue 1. Register here to access the free archive of all BMJ Journals.

Don't forget to sign up for content alerts so you keep up to date with all the articles as they are published.