Article Text

PDF
Can we climb out of the “pit” of poorly performing rapid diagnostic tests for chlamydia?
  1. Charlotte A Gaydos
  1. Dr Charlotte A Gaydos, Division of Infectious Diseases, Johns Hopkins University School of Medicine, 530 Rangos Building, 855 North Wolfe Street, Baltimore, MD 21205, USA; cgaydos{at}jhmi.edu

Statistics from Altmetric.com

Michel et al (see page 187) present documentation in this issue that a Conformitée Européenne (CE) marked home-use test for Chlamydia trachomatis that is available over the internet performs very poorly.1 The authors demonstrated a lack of accuracy of this assay compared with Amplicor PCR with sensitivities of 12.5% and 20% in both a lower (8% prevalence) and high prevalence (22.9% prevalence) population, respectively. False-positive results were equally as problematic, since the specificities were only 93.5% and 88.1% in the two populations studied. Since this test could be used by asymptomatic women, taking advantage of easy purchasing through the internet, the demonstrated positive predictive value of 28% is also unacceptable. With …

View Full Text

Request permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.

Linked Articles