Prevalence, incidence and risk factors for pharyngeal gonorrhoea in a community-based HIV-negative cohort of homosexual men in Sydney, Australia
- David J Templeton1,2,
- Fengyi Jin1,
- Leon P McNally3,
- John C G Imrie4,
- Garrett P Prestage1,
- Basil Donovan1,5,
- Philip H Cunningham3,
- John M Kaldor1,
- Susan Kippax4,
- Andrew E Grulich1
- 1National Centre in HIV Epidemiology and Clinical Research, The University of New South Wales, Sydney, Australia
- 2RPA Sexual Health, Royal Prince Alfred Hospital, Sydney, Australia
- 3SydPath, St Vincent's Hospital, Sydney, Australia
- 4National Centre in HIV Social Research, The University of New South Wales, Sydney, Australia
- 5Sydney Sexual Health Centre, Sydney Hospital, Sydney, Australia
- Correspondence to Dr David J Templeton, National Centre in HIV Epidemiology and Clinical Research, The University of New South Wales, Level 2, 376 Victoria Street, Sydney NSW 2010, Australia;
Contributors DJT performed the analyses and drafted the manuscript; AEG took overall responsibility for the project and assisted in the analyses and drafting of the manuscript; LPM performed the laboratory testing; FJ, LPM, JI, GPP, BD, PHC, SK and JMK assisted in formulating the analyses and drafting the manuscript.
- Accepted 23 August 2009
- Published Online First 19 October 2009
Background Pharyngeal gonorrhoea is common in homosexual men and may be important in maintaining community prevalence of anogenital infections.
Methods From 2003, all participants in the Health in Men cohort of HIV-negative homosexual men in Sydney were offered annual pharyngeal gonorrhoea screening by BD ProbeTec nucleic acid amplification (NAAT) assay with supplementary porA testing. Participants self-reported diagnoses of pharyngeal gonorrhoea made elsewhere between interviews. Detailed sexual behavioural data were collected 6-monthly.
Results Among 1427 participants enrolled, 65 study-visit-diagnosed pharyngeal gonorrhoea infections were identified (incidence 1.51 per 100 person-years, 95% CI 1.19 to 1.93) of which seven infections were identified on baseline testing (prevalence 0.57%, 95% CI 0.23 to 1.17%). Almost 85% of study-visit-diagnosed pharyngeal infections occurred without concurrent anogenital gonorrhoea. The combined incidence of study-visit-diagnosed and self-reported pharyngeal gonorrhoea (n=193) was 4.45 per 100 person-years (95% CI 3.86 to 5.12). On multivariate analysis, incident infection was associated with younger age (p-trend=0.001), higher number of male partners (p-trend=0.002) and reported contact with gonorrhoea (p<0.001). Insertive oro-anal sex (‘rimming’) was the only sexual behaviour independently associated with incident pharyngeal gonorrhoea (p-trend=0.044).
Conclusions The majority of pharyngeal gonorrhoea occurred without evidence of concurrent anogenital infection, and the high incidence-to-prevalence ratio suggests frequent spontaneous resolution of NAAT-detected infection. The association of pharyngeal gonorrhoea with oro-anal sex indicates that a broader range of sexual practices are likely to be involved in transmission of gonorrhoea to the pharynx than previously acknowledged. Screening the pharynx of sexually active homosexual men could play a role in reducing the prevalence of anogenital Neisseria gonorrhoeae.
- Neisseria gonorrhoeae
- prospective studies
- gay men
- neisseria gonorrhoea
Funding During the study, DJT was supported by National Health and Medical Research Council Public Health Scholarship no 351044 and, subsequently, the Royal Australasian College of Physicians GSK Scholarship for virological research. The National Centre in HIV Epidemiology and Clinical Research and the National Centre in HIV Social Research are funded by the Australian government Department of Health and Ageing. The Health in Men Cohort study was funded by the National Institutes of Health, a component of the US Department of Health and Human Services (NIH/NIAID/DAIDS: HVDDT Award N01-AI-05395), the Australian government Department of Health and Ageing (Canberra) and the New South Wales Health Department (Sydney), and the National Health and Medical Research Council (project grant no 400944).
Competing interests None.
Ethics approval Ethics approval was provided by the University of New South Wales.
Provenance and peer review Not commissioned; externally peer reviewed.