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Fourth generation point of care testing for HIV: validation in an HIV-positive population
  1. E Naylor1,
  2. D Axten2,
  3. F Makia2,
  4. C Tong3,
  5. J White2,
  6. J Fox2
  1. 1Guy's and St Thomas' NHS Foundation Trust, London, UK
  2. 2Department of GUM/HIV, Guy's and St Thomas' NHS Foundation Trust, London, UK
  3. 3Department of Virology, Guy's and St Thomas' NHS Foundation Trust, London, UK
  1. Correspondence to J Fox, Department of GUM/HIV, Guy's and St Thomas' NHS Foundation Trust, Harrison Wing, 2nd Floor Lambeth Wing, St Thomas' Hospital, London, UK; julie.fox{at}kcl.ac.uk

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Identification of primary HIV infection is valuable to reduce onward transmission and consider early antiretroviral therapy (ART). Fourth generation (4G) HIV tests detect p24 antigen in addition to antibody and therefore allow detection of HIV before antibody development. 4G point of care tests (POCTs) have been widely adopted despite an absence of prospective evidence and reports of reduced antigen sensitivity in primary HIV infection.1 The performance of the p24 component has not been evaluated in chronic infection and it is not known whether …

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