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Clinical sciences poster session 7: vaginal infections
P3-S7.04 Candida susceptibility to antifungals in Gomel region (Belarus)
  1. A Khaikova
  1. Gomel State Medical University, Gomel, Belarus

Abstract

Candidiasis is a fungal infection that often affects urogenital tract. About 75% of women had at least one episode of vulvovaginal candidiasis. Recent times chronic cause of candidiasis is prevalent in the clinical picture of the disease in Belarus. Along with Candida albicans other yasts (Candida crusei, Candida tropicans, Candida glabrata, Candida parapsilosis, etc) play a role in pathogenesis of the disease. Wide use of fluconazole in Belarus as well as prophylactic treatment during prolonged antibiotic use caused the grow of the resistance to the drug. Aim of our study was to reveal the incidence of urogenital candidiasis in patients who where checked up for STI in Gomel dermatovenereal hospital (Belarus), to study the resistance of Candida spp. to nystatin, clotrimazole, and fluconazole in vitro.

Materials and Methods We observed 4397 patients using clinical examination, microscopy, and cultural examination. Susceptibility to antifungal was studied by cultured method in vitro in 187 samples from the patients.

Results Urogenital candidiasis clinically and was diagnosed in 473 patients (10.8%) and confirmed by laboratory tests. Susceptibility to nystatin was founded in 183 cases (97.8%), to clotrimazole—in 125 cases (66.8%). Susceptibility to fluconazole was much lower and was registered only in 37 cases (19.8%).

Conclusions Candidiasis is a current problem for gynaecologists and venreologists in Belarus. Its rate reaches 10% among all patients coming for follow-up for STI. Effective treatment for candidiasis should be developed. Wide use of fluconazole should be reevaluated because of its low susceptibility.

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