Sex Transm Infect 89:357 doi:10.1136/sextrans-2012-050870
  • Commentary

Growing evidence that HPV infection is associated with an increase in HIV acquisition: exploring the issue of HPV vaccination

  1. Jennifer S Smith3
  1. 1Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA
  2. 2Perdana University Graduate School of Medicine, Serdang, Malaysia
  3. 3Department of Epidemiology, University of North Carolina, Chapel Hill, North Carolina, USA
  1. Correspondence to Dr Anne F Rositch, Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, 615 N. Wolfe St. Room E6133, Baltimore, MD 21231, USA; arositch{at}
  • Received 16 January 2013
  • Accepted 3 February 2013

The systematic review and meta-analysis by Lissouba and colleagues adds to mounting data showing a strong association between genital human papillomavirus (HPV) infection and the risk of HIV acquisition, with an estimated summary odds ratio of 2.0 (95% confidence interval 1.6 to 2.5) for HIV acquisition associated with any-HPV infection. The strongest reported estimates are specific to clearance of HPV infection, suggesting that the association between HPV and HIV acquisition may not be fully attributable to confounding by other sexually transmitted infections (STIs) or co-transmission.1 ,2 …