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P2.119 The Prevalence of Hearing Sensitivity Among HIV-Seropositive and HIV-Seronegative Men and Women
  1. M W Plankey1,
  2. H J Hoffman2,
  3. G Springer3,
  4. C Cox3,
  5. M A Young1,
  6. J B Margolick3,
  7. P Torre4
  1. 1Georgetown University Medical Center, Washington, DC, United States
  2. 2National Institute of Deafness and Communication Disorders, Bethesda, MD, United States
  3. 3Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD, United States
  4. 4San Diego State University, San Diego, CA, United States

Abstract

Background We measured the prevalence of hearing sensitivity among HIV+ and HIV- men and women and identified associated risks co-factors.

Methods Audiometric testing was conducted among 262 men [median age 54.7 years; 117 (44.7% HIV+; median (25th, 75th): nadir CD4+: 296 (191, 400); viral load (VL): 40 (40.40))] from the Baltimore-DC site of the Multicenter AIDS Cohort Study and 134 women [median age 45.2 years; 105 (78.4% HIV+; median (25th, 75th): nadir CD4+: 249 (92, 367); VL: 80 (48,1270))] from the DC site of the Women’s Interagency HIV Study. Pure-tone hearing thresholds were obtained at 500, 1000, 2000, and 4000 Hz and HL was defined as a pure tone average (PTA) ≥ 20 dB hearing level in either ear. A linear mixed model with a random-subjects effect was used to account for two repeated measurements (one per ear) adjusted for age, gender, race, HIV status, and noise exposure. The HIV+ model included nadir CD4+, peak CD8+, VL, ever having AIDS, ever monotherapy (MT), ever combination therapy (CT) and ever HAART use.

Results 84 (95.2% men, 4.8% women) HIV- and 90 (65.6% men, 34.4% women) HIV+ participants had HL in the poorer ear. Age was a statistically significant risk factor of HL, however HIV status and noise exposure were not. In the HIV+ model, nadir CD4+, peak CD8+, VL, ever having AIDS, and MT were not statistically significantly associated with HL. Although there was a higher PTA and a lower PTA with ever CT and HAART use neither was significantly associated with HL.

Conclusions We found no impact of HIV status or treatment variables on HL. HIV-infected individuals who used HAART had a lower PTA, an indicator of better hearing sensitivity. However, due to cross-sectional design of this study, it is not known whether HAART use protects hearing sensitivity.

  • HAART
  • hearing
  • HIV KL01,

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