Article Text

PDF

P3.051 Pre-Vaccination Prevalence of Infections with 25 Low-Risk Human Papillomavirus (HPV) Types Among 1000 Slovenian Women Screened For Cervical Cancer in 2010
  1. V Učakar1,
  2. M Poljak2,
  3. A Oštrbenk2,
  4. I Klavs1
  1. 1National Institute of Public Health, Ljubljana, Slovenia
  2. 2Institute of Microbiology and Immunology, Faculty of Medicine, University of Ljubljana, Ljubljana, Slovenia

Abstract

Background Our objective was to estimate pre-vaccination prevalence of cervical infections with 25 non-high-risk human papillomavirus (HPV) types, referred to as low-risk HPV (LR-HPV) types, regardless of and without the coexistence of high-risk HPV (HR-HPV) types among Slovenian women 20–64 years old screened for cervical cancer.

Methods 1000 cervical specimens randomly selected from 4455 specimens collected in the Slovenian HPV prevalence survey with a nationally wide coverage in 2010 were tested with Linear Array HPV Genotyping Test.

Results Prevalence of cervical infections with any of the 25 LR-HPV types was 10.0% (95% CI: 8.1%–11.9%) and with exclusively LR-HPV types 4.5% (95% CI: 3.2%–5.8%). Prevalence of infections with any LR-HPV types among women with normal cytology was 8.8%, with atypical squamous cells of undetermined significance (ASC-US) 30.4%, with low grade squamous intraepithelial lesions (LSIL) 60.0%, and with high grade squamous intraepithelial lesions (HSIL) 7.7%. LR-HPV types without coexisting HR-HPV types were found in 4.0% of women with normal cytology, 26.1% with ASC-US, 6.7% with LSIL, and none with HSIL. Infections with exclusively HPV 6 or HPV 11 were not found.

Conclusions LR-HPV type cervical infections without coexisting HR-HPV infections were common among Slovenian women screened for cervical cancer with ASC-US, while rare in those with pathological cytology result. With respect to organised cervical cancer screening programme in Slovenia our results suggest that HR-HPV testing based triage that complements the follow-up cytology in the Slovenian cancer screening programme since 2010, will contribute to some reduction in the Slovenian NCCSP follow-up burden, especially among women with ASC-US and some decrease in related patient anxiety.

  • HPV
  • Prevalence

Statistics from Altmetric.com

Request permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.