Background Little is known about the presence of bacterial vaginosis (BV) associated bacteria in men, but male partners of women with BV have been reported to have a high risk of urethritis. We aimed to examine the role of BV associated bacteria in urine specimens from men with and without non-gonococcal urethritis (NGU).
Methods First-pass urines were collected from 44 men with symptomatic NGU (≥ 5 PMNL/hpf) and 97 asymptomatic men without NGU (< 5 PMNL/hpf). Samples were tested for Chlamydia trachomatis(Ct), Mycoplasma genitalium(Mg), Ureaplasma urealyticum (Uu), U. parvum(Up), HSV 1 and 2, and adenovirus by PCR.
Quantitative PCRs were performed to detect Gardnerella vaginalis, BVAB 2, Eggerthella-like uncultured bacterium, Megasphaeratype 1 , Leptotrichia amnionii, Atopobium vaginae, Sneathia sanguinegens, and Prevotella sp.
Results Ct was detected in 9 (21%) cases with NGU and 1 (1%) control without NGU. Mg was detected in 10 cases (23%) and none of the controls. Corresponding figures were for Uu 4 (9%) and 26 (27%), and Up in 6 (14%) and 25 (26%), respectively. HSV type 1 was found in 2 case samples (5%). Controls were all negative for HSV. Adenovirus was found in 2 NGU samples and none of the controls. In 20 (46%) NGU cases no aetiology was found.
Conclusion G. vaginalis, BVAB-2, Eggerthella, L. amnionii, A. vaginae, S. sanguinegens and Prevotella,but not Megasphaeratype 1, had an increasing bacterial load with increasing total Ureaplasma sp. load in male urine regardless of NGU status or co-infections with known NGU pathogens. None of the BV bacteria were associated with NGU.
Correlation between total Ureaplasma sp. and BV bacterial load in all samples:
- Bacterial vaginosis associated bacteria
- non-gonococcal urethritis
Statistics from Altmetric.com
If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.