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Original article
Frequency and correlates of culture-positive infection with Neisseria gonorrhoeae in England: a review of sentinel surveillance data
  1. Hamish Mohammed1,
  2. Catherine A Ison2,
  3. Chinelo Obi1,
  4. Stephanie Chisholm2,
  5. Michelle Cole2,
  6. Nerteley Quaye2,
  7. Gwenda Hughes1
  8. on behalf the GRASP Collaborative Group
  1. 1HIV & STI Department, Centre for Infectious Disease Surveillance and Control, Public Health England, London, UK
  2. 2Sexually Transmitted Bacterial Reference Unit, Public Health England, London, UK
  1. Correspondence to Dr Hamish Mohammed, HIV & STI Department, Centre for Infectious Disease Surveillance and Control, Public Health England, 61 Colindale Avenue, London NW9 5EQ, UK; hamish.mohammed{at}phe.gov.uk

Abstract

Objectives Reference laboratories are increasingly using more sensitive rapid molecular techniques, such as nucleic acid amplification tests (NAATs), to diagnose infections with Neisseria gonorrhoeae. We determined the proportion of patients at sentinel genitourinary medicine clinics in England whose NAAT-positive diagnoses were also culture-positive for N. gonorrhoeae, and investigated whether they differed from those that were not.

Methods Behavioural and clinical data from all NAAT-positive patients reported from 23 clinics included in the Gonoccocal Resistance to Antimicrobials Surveillance Programme from July to September 2012 were included in this analysis. Unadjusted and adjusted associations between patient characteristics and culture-positive infection with N. gonorrhoeae were determined.

Results Of 3076 NAAT-positive patients, 46.4% had culture-positive infections. Most NAAT-positive patients were <35 years old (73.0%), white (67.9%), and men who had sex with men (60.1%). Women and men who had sex with men were less likely than heterosexual men to have culture-positive infections (adjusted OR (95% CI) 0.53 (0.41 to 0.68), p<0.001; and 0.74 (0.59 to 0.93), p=0.010, respectively), while those who were symptomatic (4.61 (3.92 to 5.42), p<0.001), and those presenting with infection at multiple sites (2.15 (1.76 to 2.62), p<0.001) were more likely to have culture-positive infections.

Conclusions Although gonococcal isolates were available from almost half of the NAAT-positive patients, culture was not attempted or may have failed in the remainder. Patients with culture-positive isolates were not representative of all NAAT-positive patients. Routine culture is necessary for monitoring emerging antimicrobial resistance and to inform gonorrhoea treatment guidelines.

  • ANTIBIOTIC RESISTANCE
  • GONORRHOEA
  • SURVEILLANCE

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