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Seroprevalence of 10 human papillomavirus types in the general rural population of Anyang, China: a cross-sectional study
  1. Chanyuan Zhang1,
  2. Fangfang Liu1,
  3. Qiuju Deng1,
  4. Zhonghu He1,
  5. Longfu Xi2,3,
  6. Ying Liu1,
  7. Yaqi Pan1,
  8. Tao Ning1,
  9. Chuanhai Guo1,
  10. Ruiping Xu4,
  11. Lixin Zhang4,
  12. Hong Cai1,
  13. Yang Ke1
  1. 1Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Laboratory of Genetics, Peking University Cancer Hospital & Institute, Beijing, People's Republic of China
  2. 2Department of Epidemiology, School of Public Health, University of Washington, Seattle, Washington, USA
  3. 3Department of Pathology, School of Medicine, University of Washington, Seattle, Washington, USA
  4. 4Anyang Cancer Hospital, Anyang, Henan, People's Republic of China
  1. Correspondence to Hong Cai and Yang Ke, Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Laboratory of Genetics, Peking University Cancer Hospital & Institute, No. 52 Fucheng Road, Haidian District, Beijing 100142, People's Republic of China; drhcai@gmail.com, keyang@bjmu.edu.cn

Abstract

Objectives Data on the seroprevalence of human papillomavirus (HPV) in China are limited. The objective of this study was to characterise the serological profiles of HPV infection in a rural Chinese population and help establish effective vaccine policy.

Methods Serum antibodies against the major capsid protein L1 of 10 HPV types (HPV-3, 6, 11, 16, 18, 45, 52, 57, 58 and 75) were evaluated with Luminex-based multiplex serology in a population-based study of 5548 adults (including 1587 couples) aged 25–65 years enrolled from rural Anyang, China, in 2007–2009.

Results The seroprevalence for any HPV type and any of the types HPV-6/11/16/18 was 64.8% and 34.4%, respectively. 30.3% of adults were seropositive for any mucosal high-risk (HR) HPV, and HPV-58 (10.6%), HPV-16 (9.7%) and HPV-18 (9.3%) were the three most common types. 24.8% of seropositive individuals were positive for multiple mucosal HR-HPV serotypes. Seroprevalence for most HPV types was similar among men and women. While mucosal low-risk HPV seropositivity was found to significantly decrease with age, the prevalence of antibodies to mucosal HR antigens showed a general trend of increase with age. The lifetime number of sex partners was independently associated with mucosal HR-HPV seropositivity. Positive correlation of spousal seropositivity was observed for mucosal HPV but not for cutaneous HPV.

Conclusions HPV infection was common in both men and women in rural China. HPV seroprevalence differed significantly with age, sexual behaviour and spousal infection status. These findings will be useful for evaluating and establishing HPV vaccination programmes.

  • HPV
  • SEROPREVALENCE
  • ANTIBODIES
  • CHINA
  • VACCINATION

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