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U3 Demographic associations with gonorrhoea infections in brighton
  1. Lauren Amor1,2,
  2. Fiona Cresswell2,
  3. Angela Dunne2,
  4. Gillian Dean2,
  5. Joanna Peters2,
  6. John Paul2
  1. 1Brighton and Sussex Medical School, Brighton, UK
  2. 2Brighton and Sussex University Hospitals, Brighton, UK

Abstract

Background/introduction Gonorrhoea is a public health problem due to rising incidence and antimicrobial resistance. Understanding drivers of infection locally is important for planning public health interventions.

Aim(s)/objectives Describe demographics, lifestyle factors and antimicrobial resistance of gonorrhoea infections in Brighton.

Methods A prospective study recruited 121 individuals with gonorrhoea. Participants completed a questionnaire and cultures underwent whole genome sequencing. Data from questionnaires and electronic records were anonymised and analysed.

Results Average age was 33.6 years, 7.4% were female, 91.3% were white, 80% were MSM, 6.3% bisexual males. 35.9% of MSM were HIV-positive. In MSM, multisite infection was common. MSM had on average 8 partners in 3 months before diagnosis, compared to 4 for heterosexuals. 71.6% reported visiting a sauna, sex party or the internet to find partners. Sex under the influence of drugs occurred in 39.1% of HIV-positive MSM, 36.4% of HIV-negative MSM and 27.3% of heterosexuals. Most commonly used drugs were mephedrone by MSM and cocaine by heterosexuals. Condom use was lowest in HIV-positive MSM. Previous STIs were more frequent in HIV-positive MSM, particularly syphilis (55% vs 9.1%). 66.9% were culture-positive. Resistance to >1 antibiotic occurred in 34.8% of HIV-positive MSM, 9.1% of HIV-negative MSM and 9.1% of heterosexuals.

Discussion/conclusion Condom avoidance, frequent partner change and sex under the influence of drugs are common in both HIV-positive and HIV-negative MSM, raising concerns about HIV transmission. Antibiotic resistance is more common in HIV-positive MSM, concurring with the national surveillance programme. Effective interventions targeting this group are needed.

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