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We investigated an unusual cluster of acute hepatitis B (HBV) infection among middle-aged men in East of England. Between January and August 2015, five cases of acute, symptomatic HBV cases were seen in men (median age 55 years: range 39–72), four of whom were white. All described themselves as married heterosexual men. Sequencing data showed four cases were genotype A2. Additional phylogenetic analysis showed that three were A2 …
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