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Detection of Neisseria gonorrhoeae in the pharynx and saliva: implications for gonorrhoea transmission
  1. Eric P F Chow1,2,
  2. David Lee1,
  3. Sepehr N Tabrizi3,4,5,
  4. Samuel Phillips3,5,
  5. Anthony Snow1,
  6. Stuart Cook1,
  7. Benjamin P Howden6,
  8. Irene Petalotis1,6,
  9. Catriona S Bradshaw1,2,
  10. Marcus Y Chen1,2,
  11. Christopher K Fairley1,2
  1. 1Melbourne Sexual Health Centre, Alfred Health, Melbourne, Victoria, Australia
  2. 2Central Clinical School, Faculty of Medicine, Nursing and Health Sciences, Monash University, Melbourne, Victoria, Australia
  3. 3Department of Microbiology and Infectious Diseases, The Royal Women's Hospital, Parkville, Victoria, Australia
  4. 4Department of Obstetrics and Gynaecology, University of Melbourne, Parkville, Victoria, Australia
  5. 5Murdoch Childrens Research Institute, Parkville, Victoria, Australia
  6. 6Microbiological Diagnostic Unit Public Health Laboratory, Department of Microbiology and Immunology, The University of Melbourne, at the Peter Doherty Institute for Infection and Immunity, Melbourne, Victoria, Australia
  1. Correspondence to Dr Eric P F Chow, Melbourne Sexual Health Centre, Alfred Health, 580 Swanston Street, Carlton, VIC 3053, Australia; Echow{at}mshc.org.au

Abstract

Objectives This study aimed to determine the proportion of untreated pharyngeal swabs or saliva samples positive by culture or nucleic acid amplification tests (NAATs) for Neisseria gonorrhoeae up to 14 days after an initial culture-positive pharyngeal swab.

Methods Men who have sex with men who tested positive for pharyngeal gonorrhoea at Melbourne Sexual Health Centre (MSHC) and returned to MSHC for treatment within 14 days between 13 October 2014 and 25 March 2015 were included in this study. Pharyngeal swabs and saliva samples were collected for culture and NAAT.

Results Of 33 initially culture-positive pharyngeal swabs, 32 saliva samples and 31 pharyngeal swabs were positive by NAAT and 14 pharyngeal and 6 saliva samples were positive by culture within 14 days. There was a significant decline in the proportion of repeated pharyngeal culture samples positive by culture over time (p<0.001).

Conclusions The rapid decline suggests pharyngeal gonorrhoea is short-lived, and the finding of gonorrhoea commonly in the saliva implicates this body fluid in its transmission without direct throat inoculation.

  • GONORRHOEA
  • NEISSERIA GONORRHOEA
  • GAY MEN
  • MODES OF TRANSMISSION

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