Article Text

PDF

P058 Two cases of deliberate antiretroviral overdose: raltegravir and tenofovir disaproxil fumarate/emtricitabine
  1. Emma Wainwright,
  2. Alan Tang,
  3. Fabian Chen
  1. Royal Berkshire HospItal NHS Foundation Trust, Reading, UK

Abstract

Background/introduction There is a high incidence of psychiatric illness amongst those living with HIV. This is associated with a risk of deliberate self harm including overdose with antiretrovirals. There are a small number of publications describing overdose with antiretrovirals but none describing overdose with raltegravir.

Aim(s)/objectives In this report we aim to describe two cases of overdose with antiretrovirals: the management, investigations and resultant complications.

Methods The patient case notes and laboratory test results were reviewed.

Results Case 1: A 28 year old HIV-positive man presented 96 hours after taking a deliberate overdose of 40 x 400mg raltegravir tablets. He developed mild symptoms of diarrhoea, abdominal cramps and a sore chest. Results post-overdose: electrolytes and renal function: normal; liver function tests: ALT 58, others normal; creatinine kinase 67; haematology: normal; therapeutic drug monitoring (TDM) results: raltegravir not detected 96 hours post overdose. There were no serious complications. Case 2: A 52 year old HIV-positive man presented 24 hours after taking a deliberate overdose of 18 × Truvada (tenofovir disaproxil fumarate/emtricitabine). He had no symptoms related to the overdose. Results post-overdose: urinalysis: normal; electrolytes and renal: phosphate 0.75, creatinine 94; TDM: 24 hours: 207 ng/ml; 48 hours: 80 ng/ml; 72 hours: 16 ng/ml; 192 hours: 2 ng/ml. There were no serious complications.

Discussion/conclusion The patients in our case series showed few side effects and no serious sequelae as a result of their overdose. There seems to be little guidance available to guide management of such cases.

Statistics from Altmetric.com

Request permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.