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P170 Risk factors for Mycoplasma genitalium infection in symptomatic males, females and men who have sex with men from three clinical settings in London
  1. Claire Broad1,
  2. Emma Harding-Esch2,1,
  3. Mark Harrison1,
  4. Clare Soares1,
  5. Sebastian Fuller1,
  6. Sandra Okala2,
  7. John Saunders3,2,
  8. Tristan Barber4,
  9. Phillip Hay5,
  10. Tariq Sadiq1,2
  1. 1St George’s University of London, London, UK
  2. 2Public Health England, London, UK
  3. 3Central and Northwest London NHS Foundation Trust, London, UK
  4. 4Chelsea and Westminster Hospital NHS Foundation Trust, London, UK
  5. 5St George’s University Hospitals NHS Foundation Trust, London, UK

Abstract

Background/introduction Mycoplasma genitalium (MG), a sexually transmitted infection (STI), is increasingly recognised as a cause of major reproductive health sequelae. Treatment has become increasingly difficult due to macrolide and fluoroquinolone antibiotic resistance. MG is not routinely tested for in most UK genitourinary medicine (GUM) clinics, and limited risk-factor data exist for infection in at-risk populations and in different anatomical sites.

Aim(s)/objectives To determine risk factors for MG infection in symptomatic male and female patients accessing three London GUM clinics.

Methods Patients aged ≥16 years, symptomatic of an STI (or Chlamydia, Gonorrhoea, Trichomonas vaginalis, or non-specific urethritis contact) were consented. Additional-to-routine samples provided were vulvovaginal swab (VVS) (females), first void urine (FVU) (men-who-have-sex-with-women (MSW), (men-who-have-sex-with-men (MSM)), pharyngeal and rectal swabs (MSM). Samples were tested using the FTD Urethritis Plus Test kit and positives confirmed by Polymerase Chain Reaction. Risk factors were analysed using univariate and multivariate logistic regression.

Results MG was detected in: 10.7% (95% CI 7.9%–13.5%) patients; 7.9% (95% CI 4.86%–10.94%) VVS; 19.4% (95% CI 11.76%–27.04%) MSW urine; 1.6% (95% CI 0%–4.72%) MSM urine; 0% MSM pharynx; 8.1% (95% CI 1.31%–14.89%) MSM rectum.

Abstract P170 Table 1

Risk factors associated with MG infection

Discussion/conclusion MG positivity was highest in MSW compared to the other patient groups, with younger age being the only risk factor for infection, remaining after multivariate analysis. The presence of rectal MG despite a lack of urogenital infection in MSMs warrants further investigation with a larger cohort. Overall the results indicate high MG positivity across symptomatic male and female populations.

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