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P3.72 The prevalence of anal high-risk human papillomavirus infections and associated risk factors in men-who-have-sex-with-men in cape town, south africa
  1. EE Müller1,
  2. K Rebe2,3,4,
  3. TF Chirwa5,
  4. H Struthers2,3,4,
  5. J McIntyre2,3,6,
  6. DA Lewis7,8
  1. 1Centre for HIV and Sexually Transmitted Infections, National Institute for Communicable Diseases, National Health Laboratory Service, Johannesburg, South Africa
  2. 2Anova Health Institute, Johannesburg, South Africa
  3. 3Anova Health Institute, Cape Town, South Africa
  4. 4Department of Medicine, Division of Infectious Diseases and HIV Medicine, University of Cape Town, Cape Town, South Africa
  5. 5Division of Epidemiology and Biostatistics, School of Public Health, University of the Witwatersrand, Johannesburg, South Africa
  6. 6Division of Epidemiology and Biostatistics, School of Public and Family Medicine, University of Cape Town, Cape Town, South Africa
  7. 7Western Sydney Sexual Health Centre, Western Sydney Local Health District, Parramatta, Australia
  8. 8Marie Bashir Institute for Infectious Diseases and Biosecurity and Sydney Medical School-Westmead, University of Sydney, Sydney, Australia

Abstract

Introduction We investigated the prevalence of high-risk (HR) human papillomavirus (HPV) infections and associated behavioural risk factors in men-who-have-sex-with-men (MSM) attending a clinical service in Cape Town, South Africa.

Methods MSM were enrolled at the Ivan Toms Centre for Men’s Health in Cape Town. For each participant, a psychosocial and sexual behavioural risk questionnaire was completed and an anal swab was collected and tested for 13 HR-HPV types using the Linear Array HPV Genotyping Test. Logistic regression analyses were performed to determine sexual risk factors associated with anal HR-HPV infection.

Results The median age of the 200 participants was 32 years (IQR 26–39.5), of which 31.0% were black, 31.5% mixed race and 35.5% white. The majority of the participants (73.0%) had completed high school, 42.0% had a tertiary level qualification and 69.0% were employed. The prevalence of HR-HPV types was 57.6% [95% CI: 50.3%–64.7%] in anal samples, with HPV-16 being the most common HR-HPV type detected (22.0%). HPV types 16 and/or 18, the only HR-HPV types included in all available HPV vaccines, were detected in 55 (28.8%) [95% CI: 22.5%–35.8%] anal specimens. Furthermore, 95 (49.7%) [95% CI: 42.9%–57.1%] specimens had one or more HR-HPV types included in the 9-valent HPV vaccine. Among the 88 MSM (44.0%) that were HIV positive, 81.2% [95% CI: 71.2%–88.8%] had anal HR-HPV (p=0.001). Factors that were independently associated with having anal HR-HPV infection included having sex with men only, ever engaging in group sex, living with HIV and practising receptive anal intercourse.

Conclusion HR-HPV infections in the anal canal were common among MSM in Cape Town with the highest HR-HPV burden among HIV co-infected MSM, men who have sex with men only and those that practised receptive anal intercourse. Behavioural intervention strategies and targeted HPV vaccination of young MSM are urgently required to address the high prevalence of oncogenic HPV and HIV co-infections among MSM in South Africa.

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