In order to design the suitable HIV prevention programs that help to reduce in HIV infections especially among Indian women’s, it is essential to inspect the comprehensive knowledge of HIV/AIDS and prevention methods in terms of knowledge of consistence condom use among Women’s. This paper explores comprehensive knowledge of HIV/AIDS among women’s across the different states of India. Data were drawn from the National Family Health Survey 2015–16 (NFHS-4). The study included data of women aged 15–49 years. Results clearly reveal that Comprehensive knowledge of HIV/AIDS was significantly decline in many states like Bihar, Karnataka, Madhya Pradesh and Manipur. Compared to men, women had less comprehensive knowledge of HIV/AIDS across the states of India. There is no relation built between women education and knowledge about HIV/AIDS, results portrays that despite of having 10 or more years of schooling women’s are not aware about HIV/AIDS. Even gap between knowledge about HIV/AIDS and consistent condom use among women is significantly high varies from 23 to 49 percent across different states of India. Interventions are needed to build knowledge of HIV/AIDS transmission and prevention methods through mass media campaigns, and information, education and communication programs so that women can get proper knowledge.