Introduction We assessed the immune status of mothers infected with human immunodeficiency virus (HIV) on before and after delivery in Ibadan, Nigeria. Seventy consented mothers attending the antenatal clinic were recruited and only thirty nine participated in the study. These women were followed-up until delivery and are on antiretroviral drugs.
Methods Immunologic outcomes were assessed before and after delivery using cytometry.
Results Before delivery, 20 (51%) of the women had CD4 cell count 3/cell while 19 (49%) had CD4 count cell >500 mm3/cell. At birth, 14 (36%) of the women had CD4 cell count 3/cell while 25 (64%) had CD4 cell count >500 mm3/cell.8 (40%) of the women with CD4 cell count 3/cell before delivery still had low immune status at birth while 12 (60%) had improved in CD4 cell count; also, 6 (32%) who had CD4 cell count >500 mm3/cell before delivery had low CD4 cell count at birth, while 13 (68%) had CD4 cell count >500 mm3/cell before delivery maintained high immune status at birth. Test of discordancy of immunity before and after delivery showed that there is no significant difference between CD4 cell count before and CD4 cell count at birth
Conclusion Assessment of the impact of immune status of mothers infected with HIV on birth outcomes is essential for tailoring public health measures to reduce mother-to-child transmission of HIV.