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One to One Interventions to Reduce Sexually Transmitted Infections and Under Eighteen Conceptions: A Systematic Review of the Economic Evaluations
  1. Leela Barham (leela.barham{at}
  1. NERA Economic Consulting, United Kingdom
    1. David Lewis (david.lewis{at}
    1. NERA Economic Consulting, United Kingdom
      1. Nicholas Latimer (nicholas.latimer{at}
      1. Formally of NERA Economic Consulting, United Kingdom


        Objective: To systematically review and critically appraise the economic evaluations of one to one interventions to tackle sexually transmitted infections (STIs) and teenage conceptions.

        Design: Systematic review.

        Data sources: Search of four electronic bibliographic databases from 1990 to January 2006. Search keywords included teenage, pregnancy, adolescent, unplanned, unwanted, cost benefit, cost utility, economic evaluation, cost effective*, and all terms for STIs including specific diseases.

        Review methods: We included studies which evaluated a broad range of one to one interventions to tackle STIs. Outcomes included major outcomes averted, life years, and QALYs. All studies were assessed against quality criteria.

        Results: Of 3,190 identified papers, 55 were included. The majority of studies found one to one interventions to be either cost saving or cost effective, although one highlighted the need to target the population to receive post exposure prophylaxis to reduce transmission of HIV. Most studies used a static approach which ignores the potential re-infection of treated patients.

        Conclusion: One to one interventions have been shown to be cost saving or cost effective but there are some limitations in applying this evidence to the UK policy context. More UK research using dynamic modelling approaches and QALYs would provide improved evidence, enabling more robust policy recommendations to be made regarding which one to one interventions are cost effective in tackling STIs in the UK setting. The results of this review can be used by policy makers, health economists and researchers considering further research in this area.

        • Economic Evaluation
        • Sexually Transmitted Infections

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