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Molecular epidemiology of syphilis in Scotland
  1. Michelle J Cole (michelle.cole{at}hpa.org.uk)
  1. Health Protection Agency, United Kingdom
    1. Stephanie Chisholm (stephanie.chisholm{at}hpa.org.uk)
    1. Health Protection Agency Centre for Infections, United Kingdom
      1. Helen M Palmer (helen.palmer{at}luht.scot.nhs.uk)
      1. Lothian University Health Trust, United Kingdom
        1. Lesley A Wallace (lesley.wallace{at}hps.scot.nhs.uk)
        1. Health Protection Scotland, United Kingdom
          1. Catherine A Ison (catherine.ison{at}hpa.org.uk)
          1. Health Protection Agency, United Kingdom

            Abstract

            Objective: To examine the molecular epidemiology of syphilis in Scotland.

            Methods: Ulcer specimens were collected from 85 patients with infectious syphilis. Typing of Treponema pallidum was performed using a method that examines variation in two loci; the number of 60-bp repeats within the arp gene and sequence variation in the tpr genes.

            Results: Patients were predominately white men who have sex with men. Treponemal DNA was detected in 75 specimens and a total of six subtypes were identified from 58 typeable specimens (77%). The most common subtypes were 14d (44/58, 76%), followed by 14e (7/58, 12%), 14j (3/58, 5%), 14b (2/58, 3%), 14p and 14k (1/58, 2%).

            Conclusions: This study shows that subtype 14d is the predominate subtype circulating in Scotland and there is a surprising level of genetic diversity within the Scottish men who have sex with men community.

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