Article Text

PDF
Original article
Sexual partner characteristics and incident rectal Neisseria gonorrhoeae and Chlamydia trachomatis infections among gay men and other men who have sex with men (MSM): a prospective cohort in Abuja and Lagos, Nigeria
  1. Habib O Ramadhani1,
  2. Hongjie Liu2,
  3. Rebecca G Nowak1,
  4. Trevor A Crowell3,4,
  5. Teclaire Ndomb5,
  6. Charlotte Gaydos6,
  7. Sheila Peel3,
  8. Nicaise Ndembi5,
  9. Stefan D Baral7,
  10. Julie Ake3,
  11. Man E Charurat1
  12. TRUST/RV368 Study Group
  1. 1Institute of Human Virology University of Maryland School of Medicine, Baltimore, Maryland, USA
  2. 2University of Maryland School of Public Health, College Park, Maryland, USA
  3. 3U.S. Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, Maryland, USA
  4. 4Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, Maryland, USA
  5. 5Institute of Human Virology Nigeria, Abuja, Federal Capital Territory, Nigeria
  6. 6Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
  7. 7Johns Hopkins University Bloomberg School of Public Health, Baltimore, Maryland, USA
  1. Correspondence to Dr Habib Omari Ramadhani, Division of Epidemiology and Prevention, Institute of Human Virology, University of Maryland School of Medicine, 725 W Lombard St., Baltimore, MD 21201, USA; Homari{at}ihv.umaryland.edu

Abstract

Background STIs including Neisseria gonorrhoeae (NG) and Chlamydia trachomatis (CT) potentiate HIV acquisition and transmission especially among gay men and other men who have sex with men (MSM). We investigated the influence of sexual network composition on incident rectal NG and/or CT infections among Nigerian MSM.

Methods TRUST/RV368 is a cohort of MSM recruited using respondent-driven sampling at trusted community centres in Abuja and Lagos, Nigeria. MSM respondents (egos) provided STI risk factors and demographic information for up to five of their most recent sexual partners (alters) within their sexual networks. Egos were tested for HIV, NG and CT every 3 months. Log-binomial regression was used to assess associations between alter characteristics and incident NG and/or CT.

Results Between March 2013 and October 2015, 492 MSM were longitudinally screened for STIs, of which 28.0% (n=138) were positive for incident rectal STI (61 NG only, 42 CT only and 35 NG and CT). Among egos, condom use was associated with STIs (half of the time vs never (adjusted risk ratio (aRR) 0.5; 95% CI 0.3 to 0.8), always/almost always vs never (aRR 0.7; 95% CI 0.5 to 1.0)). Incident STIs were associated with having a younger alter ≤19 versus 30 years (aRR 0.6; 95% CI 0.4 to 1.0), HIV infection (aRR 1.5; 95% CI 1.1 to 2.0) and engaging in sex under the influence of alcohol (aRR 1.4 95% CI 1.1 to 1.7) among regular alters and age ≤19 versus 30 years (aRR 0.3; 95% CI 0.2 to 0.6), HIV infection (aRR 1.4; 95% CI 1.1 to 1.8) and engaging in sex under the influence of alcohol (aRR 1.2 95% CI 1.0 to 1.4) among casual alters.

Conclusions Given the centrality of sexual partner characteristics as risks for incident STIs among Nigerian MSM, there is a need to move beyond individual interventions and syndromic surveillance and get ‘out there’ in the STI management.

Statistics from Altmetric.com

Footnotes

  • Handling editor Jackie A Cassell

  • Twitter Follow Trevor Crowell @TcrowellMD

  • Contributors HOR, MC, HL and RGN: study concept. TN: laboratory work. HOR, MC, HL, RGN and TAC: analysis and interpretation of the data. HOR, MC, HJ, RGN, TAC, SDB, JA, SP, NN and TN: drafting of manuscript. MC, HL, TAC, SDB, CG and RGN: critical revision of manuscript for important intellectual content.

  • Funding The TRUST/RV368 Study is supported by US National Institutes of Health (NIH) under award numbers R01MH099001 and R01AI120913 and by a cooperative agreement (W81XWH-11-2-0174) between the Henry M. Jackson Foundation for the Advancement of Military Medicine and the US Department of Defense. Research training for this work was supported by the NIH Fogarty International Center (D43TW001041 and D43TW010051).

  • Competing interests None declared.

  • Ethics approval The study was approved by the University of Maryland Baltimore Institutional Review Board (IRB), the Federal Capital Territory Health Research Ethics Committee, Abuja, and Walter Reed Army Institute of Research IRB.

  • Provenance and peer review Not commissioned; externally peer reviewed.

Request permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.