Regular ArticleAn Association Between LSIL and the High Secretor Phenotype of IL-1β
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Interleukin 1 beta gene polymorphism and risk of cervical cancer
2008, International Journal of Gynecology and ObstetricsCitation Excerpt :Interleukin 1 concentrations are increased in the cervicovaginal washings of women with cervical cancer [19], and women with high and intermediate IL-1 secretor phenotypes may be more susceptible to lower-grade lesions than to high-grade lesions or cervical carcinoma. The intrinsic ability to produce variable amounts of IL-1β during the various clinical stages of cervical lesions may be of immunological importance in their pathogenesis [20]. Elevated IL-1 concentrations in vaginal lavage have been associated with high odds ratios for cervical dysplasia [21] and lL-1β polymorphism has been associated with cancer among other diseases.
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