Regular ArticleCondyloma Eradication: Self-Therapy with 0.15–0.5% Podophyllotoxin versus 20–25% Podophyllin Preparations—An Integrated Safety Assessment☆
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Cited by (49)
Bioprospecting and bioassay-guided isolation of medicinal plants—A tool for drug discovery
2022, Evidence-Based Validation of Herbal Medicine: Translational Research on BotanicalsCryptic solvation dynamics of potential antineoplastic Azapodophyllotoxin: Short and long range charge transfer and distinct H-bonding motifs demystify its swinging emissive behaviour
2022, Journal of Photochemistry and Photobiology A: ChemistryCitation Excerpt :Presently, its most widely accepted semisynthetic derivatives, etoposide [9], etopophos [10] and teniposide [11] are working as anticancer drugs as DNA topoisomerase II inhibitors unlike PPT which acts as inhibitor of tubulin polymerization. However, in spite of such diverse abilities, the PPT and its derivatives are shelved on account of its intractable toxicities and severe adverse effects [12] and hence many attempts have been made to improve the cyclolignan skeleton aiming to keep the properties intact. Bearing this in mind, an emerging class of azapodophyllotoxin (AZP) [13–18] fluorophores have been introduced as nitrogen analogues of parent PPT thereby adding a new dimension in this area of clinical research.
Novel podophyllotoxin and benzothiazole derivative induces transitional morphological and functional changes in HaCaT cells
2021, Toxicology in VitroCitation Excerpt :Molecules of natural origin and their derivatives serve as scaffolds for the invention and synthesis of novel drugs. Podophyllotoxin (PPT) is the main constituent of roots and rhizomes of the plants from the genus Podophyllum belonging to Berberidaceae family (Lewis and Goldmeier, 1995; Longstaff and von Krogh, 2001; von Krogh and Longstaff, 2001). The exact mechanism of PPT action in human cells is not fully known.
Role of aneuploidy in the carcinogenic process: Part 3 of the report of the 2017 IWGT workgroup on assessing the risk of aneugens for carcinogenesis and hereditary diseases
2019, Mutation Research - Genetic Toxicology and Environmental MutagenesisCitation Excerpt :Podophyllotoxin has been shown to induce aneuploidy in hamster oocytes [248]. No oncogenic effects were seen in two 80-week mouse carcinogenicity tests dosed at up to 3.0 mg/kg/day (dermal and dietary) and in a 2-year rat dietary study at doses up to 0.3 mg/kg/day [250]. There were no data presented on plasma exposure levels in these studies.
Lignans and Neolignans: Plant secondary metabolites as a reservoir of biologically active substances
2019, Pharmacological ResearchHuman papillomavirus-related genital disease in the immunocompromised host: Part II
2012, Journal of the American Academy of DermatologyCitation Excerpt :Unpurified podophyllum was previously used as a provider-applied treatment for anogenital warts, however, because of its low efficacy, high toxicity, and a serious mutagenicity profile, it should no longer be included in recommended clinical treatment protocols, and should be entirely replaced by patient-applied, purified podophyllotoxin (level IIB evidence).32 Podophyllotoxin is preferred over podophyllum not only for its purity, stability, and lack of systemic toxicity, it has also been shown to have greater efficacy and cost effectiveness than clinic-based treatment with podophyllin (level IIB evidence),33 with the added convenience of home therapy.32-38 In a large randomized controlled trial, Lacey et al33 found that podophyllotoxin solution and cream were three and two and a half times more likely, respectively, to produce cure than podophyllin.
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