Elsevier

The Lancet

Volume 340, Issue 8811, 11 July 1992, Pages 65-69
The Lancet

ORIGINAL ARTICLES
Prevention of excess neonatal morbidity associated with group B streptococci by vaginal chlorhexidine disinfection during labour

https://doi.org/10.1016/0140-6736(92)90393-HGet rights and content

Abstract

Streptococcus agalactiae transmitted to infants from the vagina during birth is an important cause of invasive neonatal infection. We have done a prospective, randomised, double-blind, placebo-controlled, multi-centre study of chlorhexidine prophylaxis to prevent neonatal disease due to vaginal transmission of S agalactiae.

On arrival in the delivery room, swabs were taken for culture from the vaginas of 4483 women who were expecting a full-term single birth. Vaginal flushing was then done with either 60 ml chlorhexidine diacetate (2 g/l) (2238 women) or saline placebo (2245) and this procedure was repeated every 6 h until delivery. The rate of admission of babies to special-care neonatal units within 48 h of delivery was the primary end point. For babies born to placebo-treated women, maternal carriage of S agalactiae was associated with a significant increase in the rate of admission compared with non-colonised mothers (5·4 vs 2·4%; RR 2·31, 95% Cl 1·39-3·86; p=0·002). Chlorhexidine reduced the admission rate for infants born of carrier mothers to 2·8% (RR 1·95, 95% Cl 0·94-4·03), and for infants born to all mothers to 2·0% (RR 1·48, 95% Cl 1·01-2·16; p=0·04).

Maternal S agalactiae colonisation is associated with excess early neonatal morbidity, apparently related to aspiration of the organism, that can be reduced with chlorhexidine disinfection of the vagina during labour.

References (27)

  • K. Kvist Christensen et al.

    Prevention of infant colonization with group B streptococci and neonatal disease

    (1987)
  • B. Gastrin et al.

    The survival time for different bacteria in various transport media

    Acta Pathol Microbiol Scand

    (1968)
  • O. Hjalmarsson

    Epidemiology and classifications of acute, neonatal respiratory disorders. A prospective study

    Acta Paediatr Scand

    (1981)
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