Objectives: To study the clinical and epidemiological features of the first 200 AIDS patients in Hong Kong.
Method: A retrospective analysis of the data reported to the Department of Health. The patients were divided into two groups of first 100 and second 100 cases for comparison so as to discern the temporal changes.
Results: The first 100 AIDS cases were reported from February 1985 through to March 1994 (122 months) while the second 100 in the following 26 months. For both groups, they were predominantly male (94%, 89%), Chinese (66%, 74%) who acquired HIV via sex (83%, 91%). The proportion of Caucasians and homo/bi-sexual contacts in first and second 100 cases have fallen from 26% to 12% (p = 0.012), and from 53% to 31% (p = 0.006) respectively. For primary AIDS-defining illness (ADI), the frequency of Pneumocystis carinii pneumonia (PCP) has decreased (46% to 30%, p = 0.03) while that of tuberculosis (10%, 19%) and Penicillium marneffei (5%, 14%) infection have increased. Mycobacterium avium intracellualare and cytomegalovirus infection have become commoner subsequent ADIs. Frequency of PCP (22%, 9.5%) as the cause of death have dropped while that of tuberculosis has risen (4.8%, 14.3%). Median survival probability had improved from 7.3 months for the first half of patients to 11.9 months for the second half.
Conclusion: Incidence of PCP has declined among local AIDS patients whereas tuberculosis, penicilliosis, MAI, and CMV diseases have increased. Survival chance of AIDS patients has improved over the years.