RT Journal Article
SR Electronic
T1 Use of CB hamsters in the study of Treponema pertenue.
JF The British Journal of Venereal Diseases
JO Br J Vener Dis
FD BMJ Publishing Group Ltd
SP 316
OP 319
DO 10.1136/sti.55.5.316
VO 55
IS 5
A1 R F Schell
A1 J L Le Frock
A1 J P Babu
A1 J K Chan
YR 1979
UL http://sti.bmj.com/content/55/5/316.abstract
AB The CB/Ss LAK strain of inbred hamster was used as a model for studies of infection with Treponema pertenue and of acquired resistance to it. When infected, this strain developed cutaneous lesions which lasted for six to seven months, even in the presence of peak titres of antitreponemal antibody. The rate of appearance and resolution of these lesions varied with the size of the inoculum. The infected hamsters' inguinal lymph nodes increased significantly in weight and teemed with treponemes for several weeks. Animals infected for eight or 10 weeks obtained quick resolution of their lesions by treatment with penicillin and were thereafter resistant to reinfection.