PT - JOURNAL ARTICLE AU - Audrey E Pettifor AU - Catherine MacPhail AU - Stefano Bertozzi AU - Helen V Rees TI - Challenge of evaluating a national HIV prevention programme: the case of loveLife, South Africa AID - 10.1136/sti.2006.023689 DP - 2007 Aug 01 TA - Sexually Transmitted Infections PG - i70--i74 VI - 83 IP - suppl 1 4099 - http://sti.bmj.com/content/83/suppl_1/i70.short 4100 - http://sti.bmj.com/content/83/suppl_1/i70.full SO - Sex Transm Infect2007 Aug 01; 83 AB - Although 50% of all new global HIV infections occur among young people, our knowledge to date of the impact of adolescent HIV prevention interventions in developing country settings is limited. During 1999, a national HIV prevention programme for youth, called loveLife, was launched in South Africa. This paper describes the challenges faced in trying to evaluate such a national programme and the types of evidence that could be used to better understand the effect of programmes of national scale. A range of methods were planned to evaluate the programme, including national household surveys and programme monitoring data. Given the urgent need to scale-up programmes in an effort to reduce new HIV infections, a range of evidence should be assessed to measure the effect of large-scale, complex behavioural interventions as an alternative to randomised controlled trials.