@article {Friedman17, author = {S R Friedman and M Bolyard and M Sandoval and P Mateu-Gelabert and C Maslow and J Zenilman}, title = {Relative prevalence of different sexually transmitted infections in HIV-discordant sexual partnerships: data from a risk network study in a high-risk New York neighbourhood}, volume = {84}, number = {1}, pages = {17--18}, year = {2008}, doi = {10.1136/sti.2007.026815}, publisher = {The Medical Society for the Study of Venereal Disease}, abstract = {Objectives: To determine infection patterns of sexually transmitted infections that facilitate HIV transmission among HIV-discordant couples.Methods: 112 initial respondents were recruited in an impoverished neighbourhood of Brooklyn, New York. Their sexual (and injection) partners were recruited in up to four additional network sampling waves for a final sample of 465 persons aged 18 years or older. After separate informed consent had been obtained, blood and urine were collected and tested for HIV, type-specific antibodies to herpes simplex virus (HSV-2), syphilis, chlamydia and gonorrhoea.Results: Of 30 HIV-discordant partnerships, five were same-sex male partnerships and 25 were opposite-sex partnerships. No subjects tested positive for syphilis or gonorrhoea. Two couples were chlamydia-discordant. For HSV-2, 16 couples were double-positive, eight discordant, four double-negative, and two comprised a HSV-2-negative with a partner with missing herpes data.Conclusions: HSV-2 was present in 83\% of the HIV-discordant couples, chlamydia in 7\%, and syphilis and gonorrhoea in none. HSV-2 is probably more important for HIV transmission than bacterial sexually transmitted diseases because it is more widespread. Even given the limited generalisability of this community-based sample, there seems to be an important HIV-prevention role for herpes detection and prevention activities in places where HIV-infected people are likely to be encountered, including sexually transmitted disease clinics, HIV counselling and testing programmes, prisons, needle exchanges, and drug abuse treatment programmes. The effects of HSV-suppressive therapy in highly impacted groups should also be investigated.}, issn = {1368-4973}, URL = {https://sti.bmj.com/content/84/1/17}, eprint = {https://sti.bmj.com/content/84/1/17.full.pdf}, journal = {Sexually Transmitted Infections} }