RT Journal Article
SR Electronic
T1 O1-S02.02 Are there mutual associations between the incidence of HPV infection and other sexually transmitted infections after controlling for sexual behaviour?
JF Sexually Transmitted Infections
JO Sex Transm Infect
FD BMJ Publishing Group Ltd
SP A23
OP A24
DO 10.1136/sextrans-2011-050109.8
VO 87
IS Suppl 1
A1 Thing Rinda Soong
A1 P E Gravitt
A1 S B Gupta
A1 A Tadesse
A1 E Kim
A1 C Phongnarisorn
A1 V Wootipoom
A1 P Yuenyao
A1 D D Celentano
YR 2011
UL http://sti.bmj.com/content/87/Suppl_1/A23.2.abstract
AB Background We aimed to determine (i) if other sexually transmitted infections (STIs) increase the risk of incident human papillomavirus (HPV) infection and (ii) if HPV infection predicts the incidence of other STIs. Methods Women aged 20–38 years were followed semi-annually for 18 months in Thailand (n=1200). Assessment was made on cervical HPV genotypes, cervical cytology, sexual behaviour, demographic factors and diagnoses of other STIs including chlamydia, gonorrhoea, syphilis, genital herpes and trichomoniasis. Incident detection was defined as any type-specific HPV or other STI which was detected at current visit but not at previous visit. Associations were measured by ORs with 95% CIs estimated in generalised estimating equation models. Results During follow-up, 241 new cases of HPV, 110 incident cases of high risk (HR)-HPV and 46 new cases of other STIs were observed. Diagnosis of other STIs at previous visit was statistically significantly associated with twofold increased odds of any new HPV detection after controlling for sexual behaviour, age, pap smear status and contraceptive use [adjusted OR (aOR): any HPV: 2.16 (95% CI: 1.08% to 4.34%)] (Abstract O1-S02.02 table 1). No significant association was found between diagnosis of other STIs and subsequent incident detection of HR-HPV [aOR: 2.01 (95% CI: 0.74% to 5.48%)] (Abstract O1-S02.02 table 1). Positive detection of any HPV or HR-HPV predicted nearly twofold increased odds of other STIs with the estimates bordering on statistical significance [aORs: any HPV: 1.81 (95% CI: 0.94% to 3.49%); HR-HPV: 2.00 (95% CI: 0.82% to 4.83%)] (Abstract O1-S02.02 table 2). View this table:Abstract O1-S02.02 Table 1 Unadjusted and adjusted estimates of detection of other STIs on HPV incidence (total number of visit pairs=3221) View this table:Abstract O1-S02.02 Table 2 Unadjusted and adjusted estimates of HPV detection on incidence of other STIs (total number of visit pairs=3221) Conclusions We show that other STIs increase the risk of HPV incidence after controlling for sexual behaviour. The data qualitatively suggest mutual associations of HPV with other STIs. Further studies are warranted to evaluate if these reflect true biologic interactions between HPV and other sexually transmitted microbial agents, or mere confounding from unmeasured sexual risks.