Description of maternal CD4 count, antiretroviral and folate antagonist (co-trimoxazole, pyrimethamine) exposure and reported congenital abnormalities in their infants
| Child | Maternal CD4 count (×106/l)* | ART | Trimester of exposure | 1st trimester folate antagonist | Congenital abnormality |
|---|---|---|---|---|---|
| AZT = zidovudine, ddI = didanosine, ddC = zalcitabine, 3TC = lamivudine, d4T = stavudine. | |||||
| *Lowest during first trimester. | |||||
| †Medically indicated termination at 21/40. | |||||
| ‡For details see Richardson et al.10 | |||||
| §First trimster rifampicin, isoniazid, pyridoxine. | |||||
| ¶First trimester dapsone. | |||||
| 1 | 831 | AZT | 3 | No | Hydrocele |
| 2 | 250 | AZT | 2–3 | No | Polydactyly |
| 3 | N/A | AZT | 3 | No | Hydronephrosis |
| 4 | 200 | AZT | 3 | No | Polydactyly, cryptorchism |
| 5 | 143 | AZT | Intrapartum | No | Absent left testes |
| 6 | 204 | AZT, ddI, nevirapine | 3 | No | Fallot's tetralogy, DiGeorge syndrome |
| 7‡ | 60 | AZT, ddC | 1–3 | Yes§ | Hemivertebrae, butterfly vertebrae |
| 8†‡ | 29 | ddI, d4T, nevirapine | 1–2 | Yes | Spina bifida, hydrocephalus |
| 9 | 60 | 3TC, d4T | 1–3 | Yes¶ | Exomphalos |