Presence of HPV DNA in women with cervical neoplasia at enrolment, in those who developed the disease in the course of subsequent follow up, and in matched control women
| Group | Diagnosis | Total | HPV DNA positive | OR | CI | p Value |
|---|---|---|---|---|---|---|
| OR = odds ratio; CI = confidence interval. | ||||||
| Group A = women with cervical neoplasia at enrolment (mean age 35 years); group B = women with slightly suspicious cytological and/or colposcopical findings at enrolment (mean age 34 years); group C = women with normal cytological and colposcopic findings at enrolment (mean age 34 years). Control subjects were matched with the patients by age, age at first intercourse, number of sexual partners, and smoking habit. One to three controls were matched with each patient. | ||||||
| *Relative risk (RR) = not done due to zero value of HPV DNA positive controls. | ||||||
| †RR = 5.0 (CI 1.8 to 14.8). | ||||||
| ‡RR = 11.2 (CI 4.1 to 30.9). | ||||||
| §Those controls which were used with both groups B and C have been included only once in the row for groups B+C combined. | ||||||
| A | Cases | 67 | 32 (47.8%) | 18.3 | 7.4 to 44.9 | <0.0001 |
| Controls | 147 | 7 (4.8%) | ||||
| B* | Cases | 26 | 12 (46.2%) | 97.4 | 5.4 to 1745.3 | <0.0001 |
| Controls | 56 | 0 (0%) | ||||
| C† | Cases | 27 | 10 (37.0%) | 7.5 | 2.1 to 27.1 | <0.01 |
| Controls | 55 | 4 (7.3%) | ||||
| B+C‡ | Cases | 53 | 22 (41.5%) | 18.5 | 5.9 to 57.6 | <0.0001 |
| Controls | 108§ | 4 (3.7%) | ||||