Sites | Determine Syphilis TP Abbott Labs | Syphilis Fast Diesse Diagnostica | Espline TP Fujirebio Inc | Syphicheck-WB Qualpro Diagnostics | SD Bioline Syphilis 3.0 Standard Diagnostics | Visitect Syphilis Omega Diagnostics | ||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
Sens (%) | Spec (%) | Sens (%) | Spec (%) | Sens (%) | Spec (%) | Sens (%) | Spec (%) | Sens (%) | Spec (%) | Sens (%) | Spec (%) | |
*The Breslow-Day test for homogeneity of odds ratios was calculated to determine the extent of site-to-site variation of test performance. | ||||||||||||
†The κ value for each test is a summation of the overall performance of each test against the reference standard for all sites. A value of 0.75 or greater is considered excellent. | ||||||||||||
CI, confidence interval; Sens, sensitivity; Spec, specificity. | ||||||||||||
Moscow, Russian Fed. | 100 | 100 | 72 | 98 | 100 | 83 | 80 | 100 | 92 | 98 | 76 | 100 |
Birmingham, USA | 88 | 92 | 57 | 92 | 98 | 88 | 82 | 94 | 94 | 90 | 80 | 94 |
Port au Prince, Haiti | 100 | 98 | 100 | 92 | 98 | 100 | 90 | 98 | 100 | 100 | 90 | 100 |
Nanjing, China | 98 | 93 | 79 | 89 | 94 | 93 | 77 | 95 | 89 | 96 | 81 | 93 |
Mwanza, Tanzania | 96 | 94 | 94 | 90 | 98 | 100 | 80 | 100 | 94 | 94 | 82 | 100 |
Colombo, Sri Lanka | 100 | 98 | 96 | 100 | 98 | 96 | 88 | 100 | 96 | 100 | 92 | 100 |
Durban, South Africa | 96 | 90 | 94 | 96 | 96 | 94 | 82 | 100 | 94 | 98 | 86 | 100 |
Fajara, The Gambia | 100 | 88 | 94 | 86 | 100 | 92 | 96 | 94 | 100 | 84 | 92 | 96 |
Overall results | 97.2 | 94.1 | 86 | 92.8 | 97.7 | 93.4 | 84.5 | 97.7 | 95 | 94.9 | 85 | 98 |
95% CIs | 95.6 to 98.8 | 91.8 to 96.4 | 82.5 to 89.4 | 90.3 to 95.4 | 96.3 to 99.2 | 90.9 to 95.8 | 80.9 to 88.0 | 96.2 to 99.2 | 92.8 to 97.1 | 92.7 to 97.1 | 81.4 to 88.5 | 96.5 to 99.4 |
Homogeneity* p values | 0.0086 | 0.0002 | 0.2529 | 0.1427 | 0.1132 | 0.03 | ||||||
κ† (95% CI) | 0.95 (0.93 to 0.97) | 0.87 (0.84 to 0.90) | 0.95 (0.93 to 0.97) | 0.84 (0.80 to 0.87) | 0.9 (0.87 to 0.94) | 0.85 (0.82 to 0.89) |