Program in R: Hierarchical model | Assuming perfect reference standard (100%) | Assuming imperfect reference standard (90%–100%) | ||
Subgroup | Sensitivity (95% CI) | Specificity (95% CI) | Sensitivity (95% CI) | Specificity (95% CI) |
HBsAg | 94.76% (90.08 to 98.23%) | 99.54% (99.03 to 99.953%) | 96.77% (92.92 to 99.26%) | 99.89% (99.55 to 100%) |
Determine–HBsAg | 98.24% (94.74 to 99.98%) | 99.96% (99.31 to 100%) | 98.76% (94.67 to 99.99%) | 99.94% (99.49 to 100%) |
Amrad–HBs+eAg | 95.47% (88.88 to 99.44%) | 99.81% (99.33 to 100%) | 98.04% (93.39 to 99.83%) | 99.95% (99.71 to 100%) |
Anti-HBs | 93.15% (85.04 to 98.5%) | 93.08% (81.9 to 99.99%) | 99.77% (94.18 to 100%) | 96.08% (86.38 to 100%) |