Case* | Maternal stage/GA at treatment | Neonatal/infant diagnostic features | Infant age at treatment (GA at birth) | Infant age /final serologic results |
1 | Primary/postpartum | Abnormal CSF (4) | Birth (34 weeks) | 7 months/RPR NR, TPPA NR, FTA-ABS NR |
2 | Primary/postpartum | Abnormal CSF (3) | Birth (unknown) | 14 months/RPR NR, TPPA NR |
Abnormal long bone radiographs | ||||
Intraventricular haemorrhage | ||||
Fetal hydrops | ||||
3 | Primary/postpartum | Abnormal CSF (3) | Birth (38 weeks) | 10 months/syphilis EIA negative |
4 | Early latent/postpartum | Abnormal CSF (3) | Birth (30 weeks) | 5 months/syphilis EIA negative |
5 | Early latent/34 weeks GA | Abnormal CSF (3) Abnormal long bone radiographs | Birth (37 weeks) | 12 mos/syphilis EIA negative |
6 | Primary/postpartum | Abnormal CSF (3) | Birth (38 weeks) | 18 months/syphilis EIA negative |
7 | Early latent/postpartum | Abnormal CSF (4) | Birth (36 weeks) | 19 months/syphilis EIA negative |
8 | Secondary/28 weeks GA | Abnormal CSF (4) Intrauterine anaemia, hydrops, cardiomegaly, ascites. Positive syphilis PCR from intrauterine fetal blood | Birth (36 weeks) | 13 months/syphilis EIA negative |
CSF, cerebrospinal fluid; GA, gestational age; NR, non reactive; R, reactive; EIA, enzyme immunoassay; RPR, rapid plasma reagin; TPPA,Treponema pallidum particle agglutination; FTA-ABS, fluorescent treponemal antibody absorbed; PCR, polymerase chain reaction.
↵* Number of CSF abnormalities (elevated WBC, RBC or protein, low glucose, reactive VDRL).